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Paget’s Awareness Day

Paget disease
Paget disease

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Introduction to Paget’s Disease

The bone disease known as Paget’s (PAJ-its) disrupts your body’s natural recycling process, which involves the progressive replacement of old bone tissue with new bone. Bones tend to become brittle and malformed with age. In such cases, the most frequently affected areas are the legs, pelvis, skull, and spine.

Growing older and having family members with the condition raise the risk of Paget’s disease of the bones. But over the past few years, the disease has become less common and, when it does develop, is less severe for reasons that remain unknown to medical professionals. Broken bones, hearing loss, and pinched nerves in the spine are examples of complications.

The cornerstone of treatment is bisphosphonates, which are drugs that strengthen bones that have been weakened by osteoporosis. A surgical procedure might be required if problems arise.

 

History of Paget’s Disease 

Paget’s Disease of Bone is a condition whose name was given after Sir James Paget. After doing a thorough investigation into Paget’s disease, Sir James Paget published his first paper in 1877. The ailment was subsequently named Paget’s Disease of Bone. The day serves as a reminder of the continuous work being done to enhance the quality of life for those who are impacted by Paget’s disease.

 

Paget’s Awareness Day

11th of January is Paget’s Awareness Day, an opportunity to raise awareness of the disease. Although there has been significant progress in reducing the effects of the condition through research, including that funded by the Paget’s Association, much work remains. According to estimates, only 7% of people with Paget’s disease evidenced on an x-ray actually seek medical attention. Wouldn’t it be something to locate everyone suffering in silence but not yet had their illness recognized?

Being living tissue, bone often regenerates and mends itself without any issues. This process is aberrant in Paget’s disease and affects the structure of any affected bone. On the other hand, Paget’s disease can also be extremely painful and incapacitating. On occasion, a person with the condition may not even show any symptoms.

 

Why is it important to observe Paget’s Awareness Day?

  • To irradicate the isolation that is accompanied by patients with Paget’s.

Many patients with Paget’s disease may feel alone or unsupported as they cope with their chronic pain and limited mobility because the condition is not well-known. We can give individuals who suffer from Paget’s Disease a little more support in their struggles by uniting in support of advocacy on this day.

  • The celebration of Paget’s Awareness Day tends to encourage research more.

As a result of greater knowledge, an increasing number of individuals may decide to join Paget’s research. The money donated to such research association will support future studies that will help them in understanding how to lessen the symptoms of this medical condition.

  • Community gatherings honor advocates’ contributions.

January 11th is a time to get together over feasts of delectable food and celebrate the efforts of the previous year for those around the world who fight for Paget’s patients all year long. Every year on this day, the Paget’s Association organizes a number of activities for its members to get together and form friendships, such as tea parties, craft fairs, and theatrical productions.

 

How can awareness be raised on Paget’s Awareness Day in 2024?

By taking part in Paget’s Awareness Day, you can support those who are impacted by the disease and help raise awareness on it. Here are a few methods for participating:

  • Disseminate Information: 

Use social media to enlighten your friends and followers about Paget’s disease by posting educational posts, articles, and images.

  • Organize Webinars or Workshops: 

If you know the subject or have access to professionals who are, think about planning online gatherings to talk about Paget’s disease, its signs and symptoms, diagnosis, and available treatments.

  • Make Contact with Support Groups

Make connections between people who suffer from Paget’s disease and organizations or support groups that can offer them resources and help.

  • Fundraising:

Contribute to the efforts of patient support groups and researchers studying Paget’s disease.

  • Encourage Bone Health: 

Highlight the value of maintaining good bone health, including through routine examinations and lifestyle modifications that lower the risk of bone diseases.

 

Paget’s disease signs and symptoms:

Since many Paget’s disease patients do not exhibit symptoms, you might not be aware that you have the condition. Fractures or malformed bones, however, can occur and hurt. The most prevalent sign of the illness, bone pain, is occasionally confused with other illnesses like arthritis. Typically, the disease does not spread to healthy bones, and symptoms appear gradually.

Although it can affect any bone, Paget’s disease typically manifests in

  • Spine
  • Pelvis
  • Leg bones: Tibia and Femur
  • Head

Furthermore, some individuals with advanced disease may have abnormally shaped bones as well as other changes to their bones, such as:

  • An increase in the size of the head.
  • Limb shaped like a bow.
  • Curvature (curved shape) of the back.

Depending on the affected bone, additional symptoms may appear and can consist of:

  • When Paget’s disease affects the skull, it can cause headaches and hearing loss.
  • When enlarged vertebrae press against the spinal nerves, it can cause tingling and numbness in the arms and legs.
  • Hip pain can happen when the thighbone or pelvis are impacted by Paget’s disease.

Other health issues may arise depending on the bone or bones affected by Paget’s disease, including:

  • Arthritis can develop from cartilage damage in the joints.
  • Hearing loss may result from modifications to the ear and skull bones.
  • Heart failure can result from the increased workload of pumping blood throughout the body in certain individuals who already have severe Paget’s disease and heart disease.
  • Reduced blood flow to the brain and spinal cord and pressure on the brain, spinal cord, or nerves can result from enlarged bones in the skull and spine.
  • Teeth may become loose when facial bones are affected by Paget’s disease. This could make it harder to chew.
  • Paget’s sarcoma (bone cancer) is a rare side effect of Paget’s disease. (Only about 1% of patients with Paget’s disease develop Paget’s sarcoma. Most of these patients are older than 70.)

 

The disease’s impact on the blood’s calcium levels can also cause symptoms. Overactive osteoclasts may release enough calcium from the bone during bone breakdown when multiple bones in the body are affected by Paget’s disease, leading to an increased blood calcium level. Many symptoms, including the following, may result from this uncommon complication:

  • Weakness and Fatigue
  • appetite decline
  • stomach ache
  • Constipation

Paget disease

Causes of Paget’s disease

It is unknown what causes Paget’s disease of the bones. Scientists believe that the disease is caused by a mix of genetic and environmental factors. It seems that having the illness is associated with multiple genes.

Although this theory is debatable, some scientists think that Paget’s disease of the bone is linked to a viral infection in your bone cells.

Risk Factors 

The following variables may make you more susceptible to Paget’s disease of the bone:

  • Age: The disease most commonly affects people over 50.
  • Gender: Compared to women, men are impacted more frequently.
  • Nationality: In addition to the countries where European immigrants have settled, Paget’s disease of the bones is more prevalent in England, Scotland, central Europe, and Greece. In Asia and Scandinavia, it is rare.
  • Family history: You are more likely to get Paget’s disease of the bone if you have a relative who has the illness.
  • Complications: Paget’s disease of the bone usually advances slowly. For almost everyone, the illness is effectively manageable. Among the potential issues are:
  • Defects and fractures: Bones that are affected are more prone to breaking, and during repair procedures, the additional blood vessels in these malformed bones increase bleeding. Leg bones may flex, which may impair your gait.
  • Arthritis: An increased amount of stress on adjacent joints due to malformed bones can result in osteoarthritis.
  • Neurological issues: When Paget’s disease of the bone affects the spine, skull, or other regions where nerves pass through the bone, the overgrowth of bone can compress and damage the nerve, resulting in pain, tingling, or weakness in the arm or leg, as well as hearing loss.
  • Heart failure: In extreme situations, pumping blood to the afflicted parts of your body may require more effort from your heart. Heart failure may result from this increased workload occasionally.
  • Bone cancer: Up to 1% of patients with Paget’s disease of the bones develop bone cancer.

 

Diagnoses and Examinations

How is Paget’s disease of the bones diagnosed?

Due to the fact that Paget’s disease of the bone frequently exhibits no symptoms or very mild symptoms, it is frequently discovered by accident after medical professionals do a blood test or X-ray for another purpose. When diagnosing Paget’s disease of the bone, medical professionals frequently utilize X-rays.

 

What diagnostic procedures will be used to identify osteoformans or Paget’s disease of the bones?

The following examinations aid in the diagnosis of bone Paget’s disease:

  • Alkaline phosphatase blood test

If your blood has a lot of alkaline phosphatase, it may indicate that you have bone-related Paget’s disease. This blood test may be the initial indicator to medical professionals that a patient may have Paget’s disease.

  • X-rays: 

Your doctor can determine whether you have Paget’s disease-affected bones by looking at your X-ray images. In comparison to unaffected bones, affected bones appear differently in the pictures.

  • Bone scan: 

Healthcare professionals may use a bone scan to determine which bone(s) has Paget’s disease and to assess the severity of the condition. A small quantity of radioactive liquid is injected into your vein during a bone scan. 

The fluid then enters your bloodstream and travels through your bones, causing areas of bone affected by Paget’s disease to show up as “bright” on radiographs of your bones.

 

Handling and Treatment

Treatment options for bone-related Paget’s disease include:

  • Medication

Paget’s disease of the bone is treated with a variety of medications. The most typical kind are called bisphosphonates. Zoledrone is the most potent bisphosphonate available. Although this medication cannot treat bone abnormalities, it frequently produces a long-lasting remission of the disease after just one dose.

  • Surgery

To treat or mitigate bone-related complications of Paget’s disease, you may require surgery. A few surgical procedures include hip or knee replacements, bone realignment for malformed bones, and bone fracture realignment to promote better bone healing.

Frequently asked questions 

The following are a few of the Frequently asked questions, that you too may have.

  • When is the 2024 Paget’s Awareness Day?

Paget’s Awareness Day is observed on January 11th each year, offering an opportunity for individuals and organizations to participate in awareness-raising activities and educational initiatives.

  • What is the goal for celebrating Paget’s Awareness Day?

The goal of Paget’s Awareness Day in 2024 is to raise public awareness of bone disease. The abnormal formation and breakdown of bone tissue, which results in weaker and deformed bones, is the main cause of this disease. It is critical to raise awareness of this illness in order to promote prompt diagnosis and appropriate treatment.

  • What options are there for treating Paget’s disease patients?

Bisphosphonates, which impede the process of bone remodeling and thereby lessen the deforming effects of Paget’s, are the main treatment for this disease.

  • If I were to have Paget’s disease, how would I know?

Consider having a Paget’s disease blood test if you have severe pain in your limbs, spine, or skull, or if you consistently feel abnormally warm in a specific area.

  • When do symptoms start showing up?

The majority of Paget’s patients don’t have noticeable symptoms until they are older than 50.

 

Note: On January 11, please help alleviate the suffering of those who are either undiagnosed or not getting the assistance they require by supporting Paget’s Awareness Day.

 

To consult with our doctor, you can reach out to us at 0526272071.